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Abstract #0118

A pediatric brain template for myelin water fraction and diffusion tensor imaging.

Sarah R. Morris1,2,3, Richard Davis Holmes3, Adam V. Dvorak1,2, Hanwen Liu1,2, Irene Vavasour3, Silvia Mazabel4, Burkhard M├Ądler5, Shannon Kolind1,2,3,6, David K. B. Li3,6, Linda Siegel4, Christian Beaulieu7, Alex L. MacKay1,3, and Cornelia Laule1,2,3,8

1Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, 2International Collaboration on Repair Discoveries, Vancouver, BC, Canada, 3Radiology, University of British Columbia, Vancouver, BC, Canada, 4Educational and Counseling Psychology, and Special Education, University of British Columbia, Vancouver, BC, Canada, 5Phillips Healthcare, Hamburg, Germany, 6Medicine, University of British Columbia, Vancouver, BC, Canada, 7Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, 8Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada

Measuring pediatric brain myelination can provide insights into normal brain development as well as many pediatric brain disorders. We have created a myelin water and diffusion tensor template for healthy children aged 9-10 years to be used as a reference in imaging studies. Our template was produced using ANTs software to provide high-quality anatomical alignment of brain structures. ROI analysis revealed significant differences in myelin water fraction between children and adults. We found no significant correlation between myelin water fraction and diffusion tensor metrics across the ROIs investigated, highlighting the complementary information these two techniques provide.

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