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Abstract #0122

Early life Myelination Mediates the Effects of the APOE Genotype on Cognitive Development

Justin Remer1,2,3, Douglas C. Dean4, Michaela Voyer2, and Sean C.L. Deoni2

1Neurosurgery, Westchester Medical Center, Valhalla, NY, United States, 2Pediatrics, Women and Infant's Hospital, Providence, RI, United States, 3Pediatrics, Brown University Warren Alpert School of Medicine, Providence, RI, United States, 4University of Wisconsin, Madison, WI, United States

A growing focus in Alzheimer’s Disease (AD) research is understanding the earliest preclinical structural changes associated with the disorder. In prior studies our group has shown differences in early myelin content based on APOE genotype and we recently have shown preliminary results that APOE effects early longitudinal myelin and cognitive development. Nevertheless, these results fail to explain how differences in early brain anatomy lead to differences in cognitive development. This is the first study to explore and analyze if differences in early cognitive development based on APOE genotype is explained by differences in early myelin development in a large cohort of healthy neurotypical infants and young children stratified by presence or absence of at least one APOE ε4 allele.

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