Abstract #0153

Contrasting frequency shifts and QSM in a longitudinal analysis of MS lesions to determine the nature of MR frequency and QSM signal changes

Vanessa Wiggermann^1,2,3, Enedino Hernandez-Torres^2,3, Irene M Vavasour^3,4, Cornelia Laule^1,5,6, David KB Li^4,7, Anthony Traboulsee⁷, Alexander MacKay^1,3,4, and Alexander Rauscher^1,2,4

¹Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ²Pediatrics, University of British Columbia, Vancouver, BC, Canada, ³UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, ⁴Radiology, University of British Columbia, Vancouver, BC, Canada, ⁵Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, ⁶International Collaboration on Repair Discoveries (ICORD), Vancouver, BC, Canada, ⁷Medicine (Neurology), University of British Columbia, Vancouver, BC, Canada

Magnetic susceptibility and MR frequency shifts in MS lesions are sensitive measures of tissue damage. However, the sensitivity of FS and QSM to magnetic susceptibility effects as well as changes in tissue microarchitecture complicate data interpretation in biological systems. By contrasting QSM and resonance frequency shift maps these two mechanisms may be differentiated. We observed that the signal shifts at enhancement are reflective of microstructural changes indicating formation of myelin debris, as similar FS and QSM changes were observed. Signal reductions in MS lesions 5yrs-post-enhancement however are only present on QSM, suggesting removal of myelin debris and axonal loss as the underlying mechanisms.

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