Meeting Banner
Abstract #0161

In vivo mapping of liver microstructure using quantitative Temporal Diffusion Spectroscopy Imaging

Xiaoyu Jiang1, Junzhong Xu1, and John Gore1

1Vanderbilt University Institute of Imaging Science, nashville, TN, United States

Architectural and morphological changes of hepatocytes (the major parenchymal cells carrying out most of the metabolic functions of the liver) are key diagnostic findings for liver diseases and are associated with important biological events. However, such information can currently only be assessed by liver biopsy. Quantitative temporal diffusion spectroscopy imaging (qTDSI), which uses different modulated gradient waveforms to measure ADC values equivalent to the use of multiple diffusion times (Δ), has been shown to provide accurate, high-resolution maps of cell size in solid tumors. In this study, we demonstrated that qTDSI can map hepatocyte sizes in mice in vivo.

This abstract and the presentation materials are available to members only; a login is required.

Join Here