Meeting Banner
Abstract #0176

Elevated brain glutamate levels in type 1 diabetes

Evita Wiegers1, Hanne Rooijackers2, Jack van Asten1, Cees Tack2, Arend Heerschap1, Bastiaan de Galan2, and Marinette van der Graaf1,3

1Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, Netherlands, 2Internal Medicine, Radboud university medical center, Nijmegen, Netherlands, 3Pediatrics, Radboud university medical center, Nijmegen, Netherlands

Type 1 diabetes affects the structure and functioning of the brain, but the neurochemical mediators that may accompany these negative effects are largely unknown. We investigated brain metabolite levels with 1H MRS in patients with type 1 diabetes and normal awareness of hypoglycemia, patients with impaired awareness of hypoglycemia (IAH) and non-diabetic controls. Brain glutamate levels were elevated in type 1 diabetes and correlated with glycemic control and age of disease onset, but not with burden of hypoglycemia as reflected by IAH. This suggests a potential role for glutamate as early marker of hyperglycemia-induced cerebral decline in type 1 diabetes.

This abstract and the presentation materials are available to members only; a login is required.

Join Here