This study reports the first measurement of cystathionine in vivo. Cystathionine was measured using the edited magnetic resonance spectroscopy (MRS). The identification of cystathionine was confirmed by comparing in vivo spectra acquired in gliomas with the cystathionine spectrum measured in a phantom at physiological pH and temperature and with a simulated spectrum generated using accurate chemical shifts and J-coupling constants. The noninvasive detection of cystathionine by MRS may represent a new in vivo marker of glioma subtypes which will benefit diagnosis and treatment of patients with gliomas.
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