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Abstract #0181

Spiral-MRSI and tissue segmentation of normal-appearing white matter and white matter lesion load in relapsing remitting Multiple Sclerosis.

Oun Al-iedani1,2, Karen Ribbons 2,3, Jeannette Lechner-Scott2,3,4, Scott Quadrelli5, Rodney Lea2, Ovidiu Andronesi6, and Saadallah Ramadan1,2

1School of Health Sciences, University of Newcastle, Newcastle, Australia, 2Hunter Medical Research Institute, Newcastle, Australia, 3Department of Neurology, John Hunter Hospital, Newcastle, Australia, 4School of Medicine and Public Health, University of Newcastle, Newcastle, Australia, 5Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia, 6Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States

The study evaluated a novel Fast-MRSI technique with tissue segmentation in determining metabolic alterations in NAWM and WM-lesions in MS compared to healthy controls. 3D-MPRAGE and 3D-Spiral-MRSI covering 70% of total brain on 16 RRMS and 9 HCs (aged 22-55yrs) were used. MRSI was processed using MATLAB and LCModel. Findings revealed that (NAA/tCr) in WM-lesions was significantly lower than NAWM-MS and HCs. Volumetric segmentation using SIENAX, revealed a significant WBV reduction and CSF increase in RRMS compared to HCs. Fast-MRSI may enhance diagnosis and clinical monitoring of MS patients, and is sensitive in diagnosing MS even in NAWM.

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