Abstract #0186

Discrete Regions of Gray Matter Loss Underlie Major Depressive Disorder: A Replication and Expanded Investigation

Sarah C Hellewell¹, Thomas Welton¹, Jerome J Maller^1,2, Matthew Lyon¹, Mayuresh S Korgaonkar³, Stephen H Koslow⁴, Leanne M Williams⁵, Evian Gordon^1,6, A John Rush^7,8, and Stuart M Grieve^1,9

¹Sydney Translational Imaging Laboratory, Heart Research Institute, Charles Perkins Centre, University of Sydney, Sydney, Australia, ²General Electric Healthcare, Melbourne, Australia, ³The Brain Dynamics Centre, Westmead Millennium Institute and Sydney Medical School, Sydney, Australia, ⁴Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, United States, ⁵Sierra-Pacific Mental Illness Research, Education, and Clinical Center (MIRECC), Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, United States, ⁶Brain Resource Ltd, Sydney, Australia, ⁷Duke-National University of Singapore, Singapore, Singapore, ⁸Department of Psychiatry, Duke Medical School, Durham, NC, United States, ⁹Department of Radiology, Royal Prince Alfred Hospital, Sydney, Australia

The aims of this study were to construct a biomarker based on anatomical regions of profoundly reduced gray matter volume in subjects with major depressive disorder. Our biomarker successfully discriminated MDD subjects from controls at an accuracy of 73%, suggesting a possible role for network measurements of GM susceptibility in MDD.

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