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Abstract #0199

Lymphovascular invasion correlates with elevated tumor pressure as quantified by MR Elastography: initial results from a breast cancer trial

Daniel Fovargue1, Sweta Sethi2,3, Jack Lee1, Marco Fiorito1, Adela Capilnasiu1, Stefan Hoelzl1, Jurgen Henk Runge1,4, Jose de Arcos1, Keshthra Satchithananda5, Arnie Purushotham3, David Nordsletten1,6, and Ralph Sinkus1,7

1School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom, 2Guy's and St.Thomas' NHS Foundation Trust, London, United Kingdom, 3Division of Cancer Studies, King's College London, London, United Kingdom, 4Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands, 5King's College Hospital, London, United Kingdom, 6Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States, 7U1148, INSERM, Paris, France

Gauging metastatic propensity is crucial as it impacts decision making in oncology (e.g. whether a patient should receive surgery immediately or neoadjuvant chemotherapy). Interstitial fluid pressure (IFP) is known to correlate with microvascular invasion, a proxy for metastatic potential. However, no current imaging biomarkers correlate with this. We present a method to noninvasively calculate a total tumor pressure (which IFP contributes to). The method reconstructs pressure via nonlinear biomechanics and MR Elastography and is validated in simulations and phantoms. Elevated pressure values from a cohort of 16 breast cancer patients correlate with lymphovascular invasion possibly providing a much sought-after biomarker.

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