In MRI, direct myelin imaging is challenging due to the short T2* decay (less than 0.5ms) and very low proton density. In the literature, it has been reported that ultrashort echo time (UTE) imaging can directly capture the fast decaying myelin signal. To further enhance the dynamic range, adiabatic inversion recovery (IR) preparation can be utilized so that the white matter signal can be suppressed. Moreover, dual echo UTE imaging scheme can suppress the remaining gray matter signal. In this study, we explore the feasibility of IR prepared zero echo time (IR-ZTE) imaging for direct myelin imaging in the human brain.
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