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Abstract #0252

Probing Cerebral Lactate Compartmentalization with Hyperpolarized Diffusion Weighted 13C MRI

Jeremy W Gordon1, Shuyu Tang1, Xucheng Zhu1, Daniel B Vigneron1, and Peder EZ Larson1

1UCSF, San Francisco, CA, United States

Hyperpolarized 13C MRI has been used to non-invasively measure metabolism in real-time. However, perfusion and transporter expression can impact the compartmentalization of metabolites. In this work, we investigated the feasibility of diffusion weighted imaging of lactate generated from HP [1-13C]pyruvate in the human brain to assess lactate efflux and compartmentalization in a healthy volunteer. Whole brain lactate ADC values were 0.37ⅹ10-3 mm2/s, 0.29ⅹ10-3 mm2/s, and 0.41ⅹ10-3 mm2/s when diffusion gradients were applied in the X, Y, and Z direction, respectively, demonstrating the feasibility of diffusion weighted HP 13C MRI in a clinical setting.

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