To obtain rapid high isotropic resolution whole-brain T2 maps, a T2 generalized Slice-dithered enhanced resolution (T2-gSlider) acquisition/reconstruction framework is proposed. An accelerated RF-encoded multi-slab, multi-shot SE-EPI acquisition with variable TEs was developed to obtain high SNR acquisitions with reduced TR. A structured low-rank constraint was applied to reconstruct highly undersampled multi-shot data and achieve robust reconstruction for each slab. A Bloch simulated subspace shuffling model was utilized for T2 quantification and incorporated into gSlider reconstruction to further accelerate the acquisition. The proposed framework is demonstrated to enable whole-brain 1mm isotropic T2 mapping in ~40 seconds.