Glutamate is hypothesized to be the neurotransmitter in mediating BOLD fMRI. In this study, fMRI technique was combined with Magnetic Resonance Spectroscopy(MRS) to investigate the relationship between glutamate and the BOLD signal changes during face-name memory task. Three different task-based fMRI face name memory experiments were performed respectively focusing on age difference, performance level and genetic risk. [Glx]abs in left hippocampus of elderly(Experiment1), high-performance(Experiment2) and low genetic risk(Experiment3) showed high correlation with BOLD signal changes in activated regions. On the whole, glutamate appears to be excitatory and lead to compensatory excitations.