Despite a large number of studies assessing cerebral development, some of the events underlying folding of the cerebral cortex remain unclear, especially those concerning micro-architectural differences between outward (gyri) and inward (sulci) folds. The aim of this work was twofold: 1) depict cortical microstructure differences between gyri and sulci and 2) assess the potential of NODDI in the understanding of cortical folding. Gyri and sulci present different maturation timelines leading to microstructural differences. Diffusion imaging is a powerful tool to probe accurately these differences. These results are of high interest for the understanding of cortical folding process.