Despite its strong relevance in metabolism, non-invasive measurement of adipocyte size remains an unmet need. High b-value DW-MRS has been previously applied to probe diffusion restriction effects of intramyocellular lipids or brown adipocytes using preclinical systems with strong gradient systems. However, probing diffusion restriction in large lipid droplets on a clinical system remains a major challenge. The present work proposes a methodology to probe lipid droplet sizes with high b-value long diffusion time DW-MRS. The method was examined with simulations, validated in phantoms and tested to estimate bone marrow adipocyte size in the tibia of healthy subjects.
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