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Abstract #0417

Quantification of patellofemoral cartilage deformation and contact area changes in response to static loading via high-resolution MRI with prospective motion correction

Thomas Lange1, Hans Meine2,3, Elham Taghizadeh2,3, Benjamin R. Knowles1,4, Norbert P. Südkamp5, Maxim Zaitsev1, and Kaywan Izadpanah5

1Dept. of Radiology, Medical Physics, Medical Center - University of Freiburg, Freiburg, Germany, 2Department of Informatics, Medical Image Computing Group, University of Bremen, Bremen, Germany, 3Institute for Medical Image Computing, Fraunhofer MEVIS Bremen, Bremen, Germany, 4Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 5Department of Orthopedic and Trauma Surgery, Medical Center – University of Freiburg, Freiburg, Germany

Patellofemoral cartilage deformation and contact area changes in response to in situ loading were measured with high-resolution MRI. In situ loading was realized with a pneumatic loading device and motion artifacts were corrected with prospective motion correction based on optical tracking of the knee cap. Semi-automatic cartilage segmentation based on deep learning proved essential for robust quantification of the load-induced changes. Cartilage thickness and contact area showed significant and weight-dependent changes in response to loading. The patellofemoral deformation and contact mechanism under loading might be used for investigation of the knee biomechanics and as a biomarker of early-stage cartilage degeneration.

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