In vivo phosphorus magnetic resonance spectroscopic imaging (31P MRSI) enables the non-invasive mapping of absolute intra- and extracellular pH values of the human brain. However, achieving reasonable spatial resolution for studies of brain tumor patients is challenging due to low phosphate concentrations. In this study we demonstrate that 31P MRSI at 7 Tesla enables volumetric mapping of intra- and extracellular pH for studies of brain tumor patients. Volumetric pH maps with actual voxel size of 8 ml can be obtained within 30 minutes acquisition duration, and may provide novel insight into the pathophysiology of brain tumors.
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