Abstract #0489

Longitudinal structural change in skeletal muscle tissue of Duchenne muscular dystrophy patients based on 1H- and 23Na-MRI

Teresa Gerhalter^1,2,3, Lena V. Gast¹, Benjamin Marty^2,3, Regina Trollmann⁴, Frank Roemer¹, Frederik B. Laun¹, Michael Uder¹, Pierre G. Carlier^2,3, and Armin M. Nagel¹

¹Institute of Radiology, University Hospital Erlangen, FAU, Erlangen, Germany, ²NMR laboratory, Institute of Myology, Paris, France, ³NMR laboratory, CEA/DRF/IBFJ/MIRCen, Paris, France, ⁴Department of Pediatrics, Division Neuropediatrics, FAU, Erlangen, Germany

Duchenne muscular dystrophy (DMD) is a hereditary neuromuscular disease leading to progressive muscle wasting. Here, young DMD boys were examined twice within six months with a MRI protocol that included commonly used biomarkers such as fat fraction derived from the Dixon method and water T₂ as well as ²³Na MRI indices. Sodium anomalies were commonly observed and developed even in absence of fatty degenerative changes and water T₂ increases over the observational period. Although limited in the small number of subjects, the data supports that ²³Na could be used to characterize early dystrophic muscle alteration in a longitudinal fashion.

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