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Abstract #0501

Multi-Parametric MRI assessment of pulsed focused ultrasound treated pancreas tumor

Ezekiel Maloney1, Yak-Nam Wang2, Ravneet Vohra1, Tatiana Khohklova3, Stella Whang3, Helena Son3, Joshua Park1, Kayla Gravelle3, Yasser Hussaini1, Stephanie Totten3, Joo Ha Hwang3,4, and Donghoon Lee1

1Department of Radiology, University of Washington, Seattle, WA, United States, 2Applied Physics Laboratory, University of Washington, Seattle, WA, United States, 3Division of Gastroentrology, University of Washington, Seattle, WA, United States, 4Department of Medicine, Stanford, Stanford, CA, United States

Pancreatic ductal adenocarcinoma (PDA) is characterized by excessive levels of hyaluronan and collagen, resulting in a dense fibroinflammatory stroma that inhibits penetration of chemotherapeutic drugs into the tumor. Pulsed focused ultrasound (pFUS) treatment has shown promising results in disrupting the dense stroma and reducing the interstitial fluid pressure of PDA. The purpose of this study is to noninvasively assess response to pFUS treatments using quantitative MRI and to correlate the MRI results with histopathology data.

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