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Abstract #0515

Towards absolute quantification of brain metabolites using Electronic REference To access In vivo Concentrations (ERETIC) for MR spectroscopic imaging (MRSI)

Bijaya Thapa1,2, Azma Mareyam1, Jason Stockmann1,2, Boris Keil3, Philipp Hoecht4, Zhe Wang5, Yulin V. Chang5, Stefan Carp1,2, Xianqi Li1,2, Bernhard Strasser1,2, Lawrence Wald1,2, and Ovidiu C. Andronesi1,2

1Dept. of Radiology, MGH, A. A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Mittelhessen University of Applied Science, Giessen, Germany, 4Siemens Healthcare, Erlangen, Germany, 5Siemens Medical Solutions USA, Charlestown, MA, United States

Absolute quantification of metabolite concentration from MRSI data requires a reference signal of known concentration. An external synthetic electronic reference signal method (Electronic REference To access In vivo Concentrations – ERETIC) has shown great promise for absolute quantification and calibration. However, ERETIC based absolute quantification is challenging for MR spectroscopic imaging (MRSI) data and here we set on investigating strategies and performance of ERETIC in combination with MRSI and multi-channel receive arrays.

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