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Abstract #0526

Spine atrophy and sensory-motor disability in African Americans with Multiple Sclerosis

Mohamed Mounir El Mendili1, Maria Petracca1, Amgad Droby1, Giacomo Boffa2, Swetha Paduri3, Christopher Langston3, Ilena George3, Claire Riley4, Jonathan Howard5, Sylvia Klineova6, and Matilde Inglese2,7

1Neurology, Department of Neurology, Icahn School of Medicine at Mount Sinai, NEW YORK, NY, United States, 2Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Mother-Child health, University of Genoa, Genoa, Italy, 3Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 4Department of Neurology, Columbia University Medical Center, New York, NY, United States, 5Department of Neurology, New York University School of Medicine, New York, NY, United States, 6Department of Neurology, Icahn School of Medicine, New York, NY, United States, 7Department of Neurology, Radiology and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States

African Americans with multiple sclerosis (MS) present a more severe disease course than Caucasians with MS, but the contribution of spinal lesions and cervical spinal cord damage to clinical disability has never been explored.

In the present study, we investigated the extent of cervical spinal cord (CSC) damage in AA MS patients compared to age-, sex- and race matched healthy controls. Our study showed that CSC damage in terms of both macroscopic lesions and atrophy significantly impacts motor and sensory performances in AA with MS.

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