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Abstract #0546

In vivo MRI of mouse liver glycogen based on the nuclear Overhauser enhancement (NOE) with water (glycoNOE)

Yang Zhou1,2, Xiang Xu1,2, Jiadi Xu1,2, Lin Chen1,2, Yuguo Li1,2, Peter van Zijl1,2, and Nirbhay Yadav1,2

1The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional, Brain Imaging Kennedy Krieger Institute, Baltimore, MD, United States

Glycogen is abundant in different tissues and plays a central role in glucose homeostasis. We propose a new method for imaging glycogen using the nuclear Overhauser enhancement (NOE) between glycogen and water. We mapped the glycogen NOE signal in the Z-spectral range around -1 ppm from water, both in phantoms and in mouse liver in vivo. For validation, we performed a fasting protocol and glucagon infusions. Glycogen levels were greatly reduced after 24 hours fasting and after the intraperitoneal injection of glucagon (100 ml, 1mg/ml). This glycoNOE MRI has the potential for non-invasive imaging of liver glycogen levels in vivo.

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