Meeting Banner
Abstract #0558

Water mobility spectral imaging of the spinal cord: parametrization of model-free Laplace MRI

Dan Benjamini1,2 and Peter J Basser1

1National Institutes of Health, Bethesda, MD, United States, 2Center for Neuroscience and Regenerative Medicine, Rockville, MD, United States

Diffusion magnetic resonance imaging of biological systems most often results in non-monoexponential signal, due to their complexity and heterogeneity. One approach to interpreting the data without imposing microstructural models is to fit it to a multiexponential function, and to display the coefficients as a distribution of the diffusivities. Here we suggest parameterizing the measured water mobility spectra using a bimodal lognormal function. This approach allows for a compact representation of the spectrum, while also resolving overlapping spectral peaks. We apply the method on a spinal cord sample and use it to generate robust intensity images of slow and fast-diffusion components.

This abstract and the presentation materials are available to members only; a login is required.

Join Here