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Abstract #0576

Comparison and Integration of DCE- and IVIM-MRI for Breast Cancer Diagnosis: A Preliminary Study

Kurt Li1, Archana Machireddy2, Alina Tudorica2, Brendan Moloney2, Karen Oh2, Neda Jafarian2, Savannah Partridge3, Xin Li2, and Wei Huang2

1International School of Beaverton, Aloha, OR, United States, 2Oregon Health & Science University, Portland, OR, United States, 3University of Washington, Seattle, WA, United States

The goal is to compare DCE-MRI PK parameters with IVIM-MRI parameters and ADC in breast cancer diagnostic accuracy, and assess if integration of DCE and IVIM markers further improves diagnostic performance. Twenty-two patients with 23 suspicious breast lesions underwent pre-biopsy DCE- and DW-MRI with 12 b values. PK parameters were estimated using the Shutter-Speed model. IVIM parameters and ADC were derived with biexponential and monoexponential modeling of the DW-MRI data, respectively. Both DCE- and IVIM-MRI, with individual or combined markers, outperformed clinical MRI reading in breast cancer diagnosis. The integration of DCE and IVIM markers provided the best diagnostic performance.

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