Preoperative assessment of lymphovascular invasion (LVI) plays an important role in the therapeutic planning for individual breast cancer patient. A few MRI features have been shown to be associated with LVI, but remain controversial. This prospective study explored DCE-MRI-based radiomics for preoperative prediction of LVI in breast cancer. The results suggested that radiomics signature and MRI based axillary lymph node status were significantly correlated with LVI. The combined model, which incorporated the radiomics signature and MRI based axillary lymph node status, could preoperatively predict LVI with acceptable performance in the training and validation cohorts.