One of the factors determining the success of diffusion-weighted imaging of the female breast is complete fat suppression, especially when using high b-values. In this study, modified diffusion kurtosis models accounting for residual fat signal were compared to conventional DWI approaches. The comparison was based on a MR mammography dataset acquired in two study centers. The dataset comprised 198 patients with suspicious lesions detected during X-ray mammography screening. The ROC analysis shows significantly better performance of the modified diffusion kurtosis model in discriminating between malignant and benign lesions. This could improve the diagnostic accuracy regarding ambiguous mammography findings.