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Abstract #0612

Whole brain depth-dependent task based connectivity with laminar fMRI

Daniel Sharoh1, Tim van Mourik1, Lauren J. Bains1, Katrien Segaert2, Kirsten Weber1,3, Peter Hagoort1,3, and David G. Norris1,4,5

1Donders Institute, Nijmegen, Netherlands, 2Department of Psychology, University of Birmingham, Birmingham, United Kingdom, 3Max Planck Institute for Psycholinguistics, Nijmegen, Netherlands, 4Erwin L. Hahn Institute for MRI, Universit├Ąt Duisburg-Essen, Essen, Germany, 5Faculty of Science and Technology, University of Twente, Twente, Netherlands

Laminar resolution, functional magnetic resonance imaging (lfMRI) is a noninvasive technique with the potential to distinguish top-down and bottom-up signal contributions on the basis of depth-dependent interactions with distal regions. Hitherto, lfMRI has not been used to investigate whole-brain distributed networks nor complex cognitive tasks. We show here that lfMRI can reveal whole-brain directed networks during word reading. We identify language critical regions based on their association with the top-down signal stream and herewith establish lfMRI for the non-invasive assessment of directed connectivity.

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