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Abstract #0621

Product-Ratios of Metabolite Concentrations as Potential Alzheimer’s Disease Biomarker

Ariane Fillmer1, Laura Göschel2,3, Semiha Aydin1, Theresa Köbe2,3,4,5, Agnes Flöel2,3,6, and Bernd Ittermann1

1Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany, 2Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik und Hochschulambulanz für Neurologie, Charité - Universitätsmedizin Berlin, Berlin, Germany, 3Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany, 4Studies on Prevention of Alzheimer's Disease (StOP-AD) Centre, Douglas Mental Health University Institute, Montreal, QC, Canada, 5Department of Psychiatry, McGill University, Montreal, QC, Canada, 6Department of Neurology, University Medicine Greifswald, Greifswald, Germany

Previous studies have reported changes in the concentrations of several neurometabolites in Alzheimer’s disease (AD). Nevertheless, group differences of these metabolites between healthy controls, mild cognitively impaired, and AD patients remain small. The transition to ultrahigh fields enables the assessment of further metabolites, and some of them, like GABA and glutamate, have been observed to change in AD. In this study, the combination of several metabolite concentrations associated with AD into a product-ratio to serve as a stronger MRS biomarker for Alzheimer’s than individual concentrations of metabolites, and their relationship with volume of brain structures and memory performance is investigated.

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