Meeting Banner
Abstract #0656

Validation of diffusion models: a post-mortem MRI and histology study

Zihan Zhou1, Qiqi Tong1, Hongjian He1, Keqing Zhu2, Hui Lu2, Lei Zhang2, Qiuping Ding1, Laura E Jonkman3, and Jianhui Zhong1,4

1Center for Brain Imaging Science and Technology, Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrumental Science, Zhejiang University, Hangzhou, China, 2China Brain Bank and Department of Neurology in Second Affiliated Hospital, Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China, 3Department of Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam UMC, location VUmc, Amsterdam, Netherlands, 4Department of Imaging Sciences, University of Rochester, Rochester, NY, United States

The Diffusion Kurtosis Imaging (DKI) model can successfully characterize non-Gaussian diffusion. In turn, the White Matter Tract Integrity (WMTI) model is proposed to be based on the DKI model to further characterize the intra- and extra-axonal compartments. However, the accuracy with which model parameters reflect the underlying tissue characteristics has not been tested. Here, we compared two MRI model metrics using a unique combined post-mortem MRI and histopathology approach. Preliminary results show that AWF, $$$D_{e,\perp}$$$and MD from MRI correlate strongly with myelin fraction and that $$$D_{e,\parallel}$$$ from MRI correlates strongly with astrocyte fraction.

This abstract and the presentation materials are available to members only; a login is required.

Join Here