How tumour pressure components are related to tumour blood perfusion and mechanical properties
Gwenaël Pagé1, Marion Tardieu1, Laurent Besret2, Bernard Van Beers1,3, and Philippe Garteiser1
1Laboratory of Imaging Biomarker, INSERM-University Paris Diderot, Paris, France, 2Sanofi, Vitry sur seine, France, 3Department of Radiology, Beaujon University Hospital Paris Nord, Clichy, France
The purpose of this study was to assess the influence of tumour pressure components (solid stress and IFP) on blood perfusion and mechanical properties. MR elastography and perfusion measurements (FAIR method) were performed in mice with tumours xenografted subcutaneously. Tumours pressure components were measured with a catheter-transducer system. The results suggest that solid stress is the major pressure component. Both solid and fluid pressures influence perfusion and by collapsing vessels could be obstacles to drug delivery. However, the MR elastography results suggest that increased solid stress and increased mechanical properties are two distinct tumour characteristics.
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