Abstract #0809

In Vivo Multi-Color Magnetic Resonance Fingerprinting

Christian Anderson^1,2, Mette Johansen³, Bernadette Erokwu², He Hu⁴, Yuning Gu¹, Mark Griswold^1,2, Nicole Steinmetz^1,4,5, Susann Brady-Kalnay^3,6, Xin Yu^1,7, and Chris Flask^1,2,8

¹Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ²Radiology, Case Western Reserve University, Cleveland, OH, United States, ³Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, United States, ⁴NanoEngineering, University of California-San Diego, La Jolla, CA, United States, ⁵Radiology, University of California-San Diego, La Jolla, CA, United States, ⁶Neurosciences, Case Western Reserve University, Cleveland, OH, United States, ⁷Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States, ⁸Pediatrics, Case Western Reserve University, Cleveland, OH, United States

Contrast enhanced MRI studies are currently limited to observing a single contrast agent at a time. Meanwhile, optical imaging methods frequently utilize multiple fluorophores in “multi-color” imaging studies to track multiple molecular events simultaneously. We propose the novel DC-MRF method as a way to realize an analagous “multi-color” MRI. Herein, we demonstrate the first in vivo application of multi-color MRF and validate its ability to accurately and dynamically map the concentration of multiple contrast agents in vivo. This method creates the opportunity to perform a wide range of novel multi-agent MRI studies that immediately broadens the scope of contrast enhanced MRI.

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