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Abstract #0828

Reperfusion into Severely Damaged Brain Tissue is Associated with Impending Parenchymal Hemorrhage in Recanalized Acute Ischemic Stroke Patients

Samantha Jenny Ma1, Songlin Yu2,3, David S. Liebeskind2, Xin J. Qiao4, Lirong Yan1, Xin Lou5, Jeffrey Saver2, Noriko Salamon4, and Danny JJ Wang1,2

1Stevens Institute of Neuroimaging and Informatics, University of Southern California, Los Angeles, CA, United States, 2Neurology, UCLA, Los Angeles, CA, United States, 3Neurosurgery, Beijing Tiantan Hospital, Beijing, China, 4Radiology, UCLA, Los Angeles, CA, United States, 5Radiology, Chinese PLA General Hospital, Beijing, China

While timely reperfusion can reduce more extensive brain tissue injury by salvaging reversibly damaged penumbra, late recanalization also carries the risk of causing additional and substantial brain damage, such as ischemia-reperfusion injury, compared with no revascularization. The reperfusion status after thrombolysis within the DWI lesion territory and its relationship with HT is unclear, leaving the details regarding post-treatment care unspecified. In this study, we aim to quantify the volume of reperfusion into severely damaged brain tissue and investigate its predictive value for impending parenchymal hematoma following recanalization.

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