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Abstract #0844

Optimization of time-encoded pseudo-continuous ASL angiography with a variable flip-angle scheme

Joseph G. Woods1, S. Sophie Schauman1, Mark Chiew1, Michael A. Chappell2, and Thomas W. Okell1

1Wellcome Center for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom, 2Insitute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom

Time-encoded PCASL angiography is an attractive method for deriving some, or all, of the desired temporal information from the PCASL preparation rather than a dynamic readout. Higher flip-angles can then be used for the remaining excitation pulses in the readout, increasing the signal-to-noise ratio of the angiograms.

However, use of constant flip angles across all excitations leads to abrupt signal changes between images constructed from different time-encoding blocks. A variable flip-angle scheme is presented, which maintains a constant signal across all excitations, removes these discontinuities and ensures optimal signal levels across all images.

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