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Abstract #0860

Serial characterization of HP [1-13C]pyruvate metabolism in the brains of patients with glioma and healthy controls

Adam W Autry1, Jeremy W Gordon1, Hsin-Yu Chen1, Daniele W Mammoli1, Marisa Lafontaine1, Javier Villanueva-Meyer1, Susan M Chang2, Duan Xu1, Peder EZ Larson1, Daniel B Vigneron1,3, Sarah J Nelson1,3, and Yan Li1

1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States, 3Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, United States

Serial dynamic hyperpolarized [1-13C]pyruvate imaging was performed on 3 patients undergoing treatment for recurrent brain tumors and 2 healthy controls using a frequency-specific EPI sequence (20 total scans). To evaluate metabolism within normal-appearing white matter (NAWM), rate constants for pyruvate-to-lactate (kPL) and pyruvate-to-bicarbonate (kPB) conversion were kinetically modeled. Healthy control data provided reference rate constants in NAWM and demonstrated replicabililty of test-retest type scans across hardware platforms. Serial patient data also showed similar, replicable data with standard-of-care treatment, as well as evidence that kPL, NAWM is increased 148-290% following administration of anti-angiogenic agent Bevacizumab, which promotes vascular normalization.

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