In neuro-surgical preoperative planning of extirpation of large tumors it is important to locate the paths of critical cerebral nerve fiber bundles (e.g. corticospinal-tract). Manual fiber bundle selection is elaborate, requires expert knowledge and is prone to user errors. Therefore, in this study a fully automatic pipeline for white matter bundle segmentation was setup, incorporating recently published white matter bundle segmentation based using DNN, and tested with 12 patients suffering from large brain lesions. In all cases the position of the corticospinal tracts was evaluated as plausible, although in at least one hemisphere this tract was affected by the lesion.