Abstract #0941

Efficient whole-brain tract-specific T1 mapping with slice-shuffled inversion-recovery diffusion-weighted imaging at 3T

Daniel A. Andrews^1,2, Jennifer S. W. Campbell¹, Ilana R. Leppert¹, Daniel J. Park³, G. Bruce Pike^1,2,4,5, Jonathan R. Polimeni^3,6,7, and Christine L. Tardif^1,2,8

¹McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada, ²Department of Biomedical Engineering, McGill University, Montreal, QC, Canada, ³Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ⁴Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, ⁵Department of Radiology and Department of Clinical Neuroscience, University of Calgary, Calgary, AB, Canada, ⁶Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, ⁷Department of Radiology, Harvard Medical School, Harvard University, Boston, MA, United States, ⁸Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada

The majority of voxels in magnetic resonance images of human white matter contain crossing tracts. Conventional T₁ mapping techniques are sensitive to the myelin content of the entire voxel and are thus non-specific to individual tract myelination. We recently proposed an efficient slice-shuffled, multiband accelerated inversion-recovery diffusion-weighted MRI (IR-DWI) sequence at 3 Tesla. Here we demonstrate that IR-DWI can be used to estimate tract-specific T₁ in voxels with crossing fibres in a phantom and in a healthy subject in a reasonable scan time.

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