Abstract #0944

3D-EPTI for Ultra-fast Multi-contrast and Quantitative Imaging

Fuyixue Wang^1,2, Zijing Dong^1,3, Timothy G. Reese¹, Lawrence L. Wald^1,2, and Kawin Setsompop^1,2

¹Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, ²Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States, ³Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, United States

A new technique, 3D-EPTI with inversion-recovery-prepared gradient- and spin-echo readouts, was developed to rapidly acquire a time-series of distortion- and blurring-free multi-contrast images. The technique relies on a new ‘time-resolved’ multi-shot 3D-EPI readout with a hybrid spatio-temporal CAIPI and golden-angle radial-blade sampling scheme. With just about 2 minutes of 3D-EPTI acquisition, thousands of brain volume data at 1.1 mm isotropic resolution can be generated at different TIs and TEs, capturing signal evolution of T₁ inversion recovery interspersed with T₂/T₂^* decay, enabling rapid simultaneous quantitative parameters estimation.

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