Modern magnetic resonance spectroscopic (MRS) pulse sequences frequently overlook the issue of unwanted coherence pathways as source of numerous spectral artifacts. A novel and robust algorithm which only requires the input of the desired coherence pathway was developed to efficiently dephase all unwanted coherence pathways for any MRS pulse sequence. Experiments were performed on phantoms and healthy volunteers comparing crusher schemes obtained from the literature with those obtained from the optimization algorithm for sLASER and MEGA-sLASER. The results demonstrate that the effects of unwanted coherences can be drastically reduced through the implementation of an optimized crusher and phase cycling scheme.
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