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Abstract #0962

Distinctive structural connectivity between cognitively impaired and nonimpaired active professional fighters

Virendra R Mishra1, Karthik R Sreenivasan1, Xiaowei Zhuang1, Zhengshi Yang1, Sarah J Banks2, Dietmar Cordes1, and Charles Bernick3

1Imaging Research, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 2University of California, San Diego, San Diego, CA, United States, 3Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States

Using neuropsychological scores from the Professional Fighters Brain Health Study (PFBHS), this study first identified 70 cognitively impaired active professional fighters, and then matched 70 nonimpaired fighters matched on demographics, and other fighting criteria. Utilizing cortico-cortical connectivity obtained from diffusion MRI (dMRI) dataset, this study identified that there is an overall lower structural connectivity strength in cognitively impaired fighters suggesting that repeated head trauma induces a global brain shift in fighters experiencing cognitive decline.

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