Abstract #0979

“3D-Stars” Cine MRI for the Coronary Arteries: Feasibility of Volumetric Endothelial Function Assessment

Gabriele Bonanno^1,2, Robert G Weiss^1,2, Davide Piccini^3,4, Jérôme Yerly^4,5, Sahar Soleimanifard^1,2, Li Pan⁶, Xiaoming Bi⁷, Allison G Hays¹, Matthias Stuber^4,5, and Michael Schär²

¹Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Division of MR Research, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ⁴Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, ⁵Center for Biomedical Imaging (CIBM), Lausanne, Switzerland, ⁶Siemens Healthineers, Baltimore, MD, United States, ⁷Siemens Healthineers, Los Angeles, CA, United States

2D coronary cine MRI has been shown to noninvasively assess coronary endothelial dysfunction, which is an early manifestation of atherosclerosis and a predictor of future acute events. However, atherosclerosis is a diffuse process and a 2D approach can only provide local measures. Recently, we introduced “3D-Stars”, a free-breathing golden-angle 3D stack-of-stars cine sequence with isotropic spatial resolution to image the proximal and mid segments of the right coronary artery. Here, we show excellent image quality at rest and during isometric-handgrip stress acquisitions and feasibility for assessing normal coronary endothelial function along the vessel in a small cohort of healthy subjects.

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