Abstract #0998

Assessing Human Optic Nerve Function using Diffusion Basis Spectrum Imaging (DBSI)

Tsen-Hsuan (Abby) Lin¹, Peng Sun¹, William M Spees^1,2, Ajit George¹, Hsin-Chieh Yang¹, Michael Wallendorf³, Anne H Cross^2,4, Junqian Xu⁵, and Sheng-Kwei Song^1,2,6

¹Radiology, Washington University School of Medicine, St Louis, MO, United States, ²Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, United States, ³Biostatistics, Washington University School of Medicine, St Louis, MO, United States, ⁴Neurology, Washington University School of Medicine, St Louis, MO, United States, ⁵Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁶Biomedical Engineering, Washington University in St. Louis, ST. LOUIS, MO, United States

Previously, we employed diffusion fMRI to assess mouse optic nerve activation in response to flashing-light visual stimulation. Perpendicular apparent diffusion coefficient (ADC_⊥) decreased independent of vascular effects. In the current study, we applied DTI and diffusion basis spectrum imaginig (DBSI) to assess human optic nerve activation with flashing checkerboard stimulation. We observed 43% and 13% decrease of DBSI λ_⊥ and λ_ǁ, respectively, but not in DTI.

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