Abstract #1015

Quantitative characterization of a capillary-network MRI phantom using restricted diffusion analysis

Astrid Mayr^1,2, Moritz J. Schneider^1,3, Thomas Gaass^1,3, Katia Parodi⁴, Jens Ricke¹, Julien Dinkel^1,3, and Olaf Dietrich¹

¹Department of Radiology, LMU University of Munich, Munich, Germany, ²German Center for Vertigo and Balance Disorders, LMU University of Munich, Munich, Germany, ³Comprehensive Pneumology Center, German Center for Lung Research, Munich, Germany, ⁴Experimental Physics - Medical Physics, LMU University of Munich, Garching, Germany

An artificial 3D capillary-network phantom (made out of melt-spun sugar fibers) was characterized with diffusion-time-dependent diffusion-weighted MRI. Restricted diffusion was analyzed based on a two-compartment (cylinders and spheres) model; diffusion coefficients were simulated with a simple random-walk model of spins in 2D and 3D spherical geometries. The best model fit agreed very well with the measured diffusion-time-dependent diffusion coefficients and resulted in a mean diameter of 142±2 µm of the spheres and a mean diameter of 9.7±0.7 µm of the capillary tubes (cylinders) with a capillary fraction of f_cyl=35±1%.

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