Abstract #1018

# Comparison of Tumor Water Exchange Rate and Intracellular Water Lifetime Measured by Diffusion MRI

Jin Zhang1 and Sungheon Gene Kim1

1Radiology, New York University School of Medicine, New York, NY, United States

In vivo measurement of cellular-interstitial water exchange rate remains non-trivial. Its development is also hampered by the lack of a gold standard method for validation. In this study, we have used two complementary diffusion MRI methods to measure the water exchange rates. Time-dependent diffusional kurtosis imaging was used to measure the water exchange rate ($$\tau_{ex}$$$) between the intra- and extra-cellular spaces, while a constant gradient diffusion MRI experiment was used to measure the intracellular water lifetime ($$\tau_i$$$). These two measurements were conducted using GL261, a mouse glioma tumor model.

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