Abstract #1020

Repeatability and Reproducibility of Confounder-Corrected R2* as a Biomarker of Liver Iron Concentration: Interim Results from a Multi-Center, Multi-Vendor Study at 1.5T and 3T

Diego Hernando^1,2, Ruiyang Zhao^1,2, Valentina Taviani³, Mounes Aliyari Ghasabeh⁴, Li Pan⁵, Qing Yuan⁶, Stefan Ruschke⁷, Dimitrios C. Karampinos⁷, Xiaodong Zhong⁸, Ryan J. Mattison⁹, Ihab R. Kamel⁴, Ivan Pedrosa⁶, Shreyas Vasanawala¹⁰, Takeshi Yokoo^6,11, and Scott B. Reeder^1,2

¹Radiology, University of Wisconsin-Madison, Madison, WI, United States, ²Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ³Global MR Applications & Workflow, GE Healthcare, Menlo Park, CA, United States, ⁴Radiology, The Johns Hopkins University, Baltimore, MD, United States, ⁵Siemens Healthineers, Baltimore, MD, United States, ⁶Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁷Radiology, Technical University of Munich, Munich, Germany, ⁸Siemens Healthineers, Los Angeles, CA, United States, ⁹Medicine, University of Wisconsin-Madison, Madison, WI, United States, ¹⁰Radiology, Stanford University, Palo Alto, CA, United States, ¹¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States

R2* mapping has the potential to provide rapid and reliable quantification of liver iron concentration. Importantly, previous studies have demonstrated that by correcting for relevant confounding factors (eg: noise floor effects and fat) R2* mapping is highly insensitive to the presence of these confounders. However, the repeatability and reproducibility of confounder-corrected R2* across multiple sites and vendors remains unknown. This abstract reports interim results from a multi-center, prospective, NIH-sponsored liver iron quantification study. Our results suggest excellent repeatability and reproducibility of confounder-corrected R2* for liver iron quantification in patients, across four centers, three vendors and at both 1.5T and 3T.

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