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Abstract #1027

Detection of Early Hepatic Inflammation in Obese Patients with MR Elastography (MRE)

Jiahui Li1, Alina Allen2, Sudhakar K. Venkatesh1, Taofic Mounajjed3, Jun Chen1, Kevin J. Glaser1, Armando Manduca1, Vijay Shah2, Richard L. Ehman1, and Meng Yin1

1Radiology, Mayo Clinic, Rochester, MN, United States, 2Gastroenterology, Mayo Clinic, Rochester, MN, United States, 3Anatomic Pathology, Mayo Clinic, Rochester, MN, United States

We performed multifrequency MRE in 10 controls and 88 patients underwent bariatric surgeries. A total of 38 patients were reassessed one year later with MRE and biopsy. At the initial exam, MRE-assessed loss modulus (imaginary component of the complex shear modulus) at 30Hz was significantly higher in obese patients compared with controls, even those without elevated liver fat. The elevation in loss modulus became normalized after treatment. In summary, MRE-assessed loss modulus shows promise as a sensitive indicator of early hepatic inflammation or cell injury in obese patients, pointing to a potential role in selection of patients for bariatric surgery.

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