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Abstract #1051

Triple network activity regulation mediated by the insular cortex in the mouse brain.

Francesca Mandino1,2, Ling Yun Yeow1, Chai Lean Teoh1, Heidi E Foo1, Renzhe Bi1, Jiayi Zhang1, Nathaniel Low1, Tricia Lim1,3, John Gigg2, Olivo C. Malini1, Yu Fu1, and Joanes Grandjean1

1Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore, Singapore, 2Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom, 3University College London, London, United Kingdom

The triple-network model is a contemporary theoretical framework derived from empirical neuroimaging data to explain a wide range of observations stemming from multiple psychopathologies. Central to the model are interactions between the salience, default-mode, and central executive networks. The insula area is a central node of the salience network. Using acute photostimulation, we report evidence to support the existence of a triple-network system within the mouse brain. Further, by using sustained optogenetic neuromodulation, we show that inhibition of the insular area acts on homotopic functional connectivity but fails to affect wider interactions within triple-network system in a resting-state setting.

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