Prediction of Ischemic Placental Disease during Early Gestation using Pseudo-Continuous Arterial Spin Labeling MRI
KyungHyun Sung1, Dapeng Liu1, Xingfeng Shao2, Alibek Danyalov1, Teresa Chanlaw3, Danny JJ Wang2, Carla Janzen4, and Sherin U Devaskar3
1Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, 2Mark & Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, United States, 3Department of Pediatrics, University of California, Los Angeles, Los Angeles, CA, United States, 4Department of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, CA, United States
A real-time and non-invasive way to assess placental development would have great potential to help diagnose various conditions of placental insufficiency. Arterial spin labeling (ASL) MRI has great potential to serve as reliable imaging tool to monitor blood flow in the placenta during early gestation. We compute two new imaging parameters, high placental blood flow (hPBF) and relative hPBF, using pseudo-continuous ASL and assess associations between the imaging parameters and pregnancy outcomes, ischemic placental disease (IPD). Of the parameters, the difference in hPBF and relative hPBF at 16 weeks were most pronounced between normal and IPD subjects.
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