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Abstract #1118

Advances in direct myelin imaging

Markus Weiger1, Romain Nicolas Froidevaux1, David Otto Brunner1, Manuela Barbara Rösler1, and Klaas Paul Pruessmann1

1Institute for Biomedical Engineering, ETH and University of Zurich, Zurich, Switzerland

Direct imaging of myelin is of great interest for improved diagnosis of neurodegenerative diseases. However, MR signals from myelin exhibit ultra-short T2 values in a range of 8 μs - 1 ms with a large fraction below 100 μs. Due to restrictions in sequence timing, current short-T2 imaging approaches cannot sufficiently capture these very short signals. In the present work, advanced short-T2 methodology and hardware are employed to actually image the majority of the ultra-short-T2 components in the brain. The abilities of the approach are proven in excised brain tissue and applied in vivo.

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