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Abstract #1158

Flow quantification in portal hypertension with 4D flow: comparison of a free breathing k-t accelerated sequence to a respiratory-navigated sequence

Octavia Bane1,2, Daniel Stocker1,2, Paul Kennedy1,2, Stefanie Hectors1,2, Scott Friedman3, Thomas Schiano3, Maria Isabel Fiel4, Swan Thung4, Emilie Bollache5,6, Susanne Schnell5, Aaron Fischman7, Michael Markl5,8, and Bachir Taouli1,2

1Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 3Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 4Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 5Radiology, Northwestern University, Chicago, IL, United States, 6Laboratoire d'Imagerie Biomedicale, INSERM, Paris, France, 7Department of Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 8Biomedical Engineering, Northwestern University McCormick School of Engineering, Evanston, IL, United States

The purpose of our prospective study was to compare a free-breathing k-t GRAPPA accelerated 4D flow sequence with a standard navigator-gated sequence, and to correlate hemodynamic parameters to the hepatic venous pressure gradient (HVPG) in patients with chronic liver disease. The k-t accelerated sequence had significant (three-fold) reduction in acquisition time, while obtaining equivalent image quality and quantitative parameters in the large vessels as the standard sequence. However, there was systematic under-estimation of velocities in small arteries. Time-average velocity in the superior mesenteric vein measured with the k-t sequence was positively correlated with HVPG.

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