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Abstract #1182

Rapid, Time-Resolved Brain Imaging with Multiple Clinical Contrasts using Wave-Shuffling.

Siddharth Srinivasan Iyer1,2, Daniel Polak1,3,4, Congyu Liao1, Steve Cauley1, Berkin Bilgic1, and Kawin Setsompop1

1Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, 3Department of Physics and Astronomy, Heidelberg University, Heidelberg, Germany, 4Siemens Healthcare GmbH, Erlangen, Germany

Previously, we presented Wave-Shuffling: a technique that combines random-sampling and the temporal low-rank priors of T2-shuffling with the sinusoidal gradients of Wave-CAIPI to achieve highly-accelerated, time-resolved acquisitions. In this work, we optimize and apply Wave-Shuffling to T2-SPACE and MPRAGE to achieve rapid, 1 mm-isotropic resolution, time-resolved imaging of the brain where we recover a time-series of clinical contrast. We also present preliminary explorations into Joint-Contrast Wave-Shuffling to boost signal-to-noise ratio and reconstruction-conditioning at high accelerations.

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